Inhalation liquid 99.9% methoxyflurane
PENTHROX® is a medicine which is used to reduce pain.
It is inhaled through the PENTHROX® INHALER.Pain relief should start after 6-10 breaths (1-3 minutes). PENTHROX® is intended to reduce the severity of pain.PENTHROX® belongs to a family of medicines called inhalation anesthetics. At the recommended dose, PENTHROX® provides pain relief without producing anesthesia.PENTHROX® is simple: Easy to set up. Easy to use.PENTHROX® is suitable for moderate to severe pain associated with a wide-range of trauma injuries.PENTHROX® shows superiority for the relief of moderate to severe trauma pain compared to standard analgesics in all emergency settings.
Easy and practical for healthcare professionals:
- A non-opioid, non-controlled drug, emergency analgesic.
- Simple, fast setup – no need for signatories, canisters or cannulas.
- May avoid the need for procedural sedation.
Easy and effective for patients:
- Breathe as normal through the inhaler to receive analgesia.
- Simple self-administration process (under supervision of a person trained in its administration).
Trauma pain: Dislocations, Lacerations/wounds, Fractures, Burns/Scalds, Chest/Abdominal Injuries, Neck of Femur and Fracture. Penthrox provides a safe analgesic for patients requiring minor procedures. Children and adults can inhale Penthrox for 1-2 minutes prior to starting a painful procedure such as IUD insertion, Suturing and gluing, Skin lesion excision, Vaccinations, and Wound dressing.
Contraindication and side effects:
Before you are given PENTHROX®
You must not be given PENTHROX® if you have an allergy to methoxyflurane, other inhalation anesthetics or any of the ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction may include: Shortness of breath, wheezing, or difficultly to breathe swelling of the face, lips, tongue, or other parts of the body Rash, itching, or hives on the skin
You must not be given PENTHROX® if you have, or are suspected of having, an inherited tendency for a condition called malignant hyperthermia. This is a condition where, when you or a related family member has been given an anaesthetic, symptoms such as a very high fever, fast, irregular heartbeat, muscle spasms, and breathing problems have occurred.
You must not be given PENTHROX® if you have heart disease, kidney disease or reduced function of your kidneys, difficulty breathing, or head injury.
PENTHROX® should only be used if the package is undamaged and the expiry date marked on the bottle has not passed.
Tell your healthcare professional if you have allergies to: any other medicines, any other substances such as foods, preservatives or dyes or any ingredients listed at the end of this information leaflet
Tell your healthcare professional if you are pregnant or intending to become pregnant. Your healthcare professional will discuss the possible risks and benefits of being given PENTHROX® during pregnancy.
Tell your healthcare professional if you are breast-feeding or intending to breast-feed. Your healthcare professional will discuss the possible risks and benefits of being given PENTHROX® during breast-feeding.
Tell your healthcare professional if you have, or have had, any medical conditions, especially the following: Kidney problems, Liver problems.
If you have not told your healthcare professional about any of the above, tell them before you are given PENTHROX®. You may still be able to use PENTHROX®, but your healthcare professional will need to assess the risks against the potential benefits.
Taking other medicines
Tell your healthcare professional if you are taking any other medicines, including medicines that you buy without a prescription at the chemist, supermarket or health food shop.
Some medicines and PENTHROX® may interfere with each other. Your healthcare professional needs to know if you are taking any of these medicines to accurately assess the risks and benefits of administering PENTHROX®. These include:
- Isoniazid to treat tuberculosis
- Barbiturates, such as phenobarbital to treat epilepsy
- Rifampicin to treat infection
- Medicines, or illegal drugs, that have a dampening effect on the nervous system such as narcotics.
- Antibiotics or other medicines that may harm the kidney such as tetracycline, gentamicin, kanamycin, colistin, polymyxin B, cephaloridine or, amphotericin B
- Intravenous adrenaline
- β-blockers to treat hypertension
Your doctor may have more information on medicines to be careful with around the time you receive PENTHROX®.
Step by step guide
STEP 1: ENSURE ATTACHMENT
Ensure the Activated Carbon (AC) Chamber is inserted into the dilutor hole on the top of the PENTHROX inhaler.
STEP 2: FILL & ROTATE
Tilt the PENTHROX Inhaler to a 45° angle and pour the total contents of one PENTHROX bottle into the base of the Inhaler whilst rotating.
STEP 3: BREATHE
Place wrist loop over patient’s wrist. Patient inhales and exhales through the mouthpiece to obtain analgesia. First few breaths should be gentle and then breathe normally through Inhaler. If stronger analgesia is required, patient can cover dilutor hole on the AC Chamber with finger during use. A second dose can be used if required.
The maximum dose in a single day should not exceed 6 ml (two bottles of methoxyflurane).
This could provide up to a maximum of two hours of analgesia.
The maximum dose in a week should not exceed 15 ml1